反应详情

To a solution of methyl 5-(1,1-dioxido-1,2-thiazinan-2-yl)-8-{[(4-methylphenyl)sulfonyl]oxy}-1,6-naphthyridine-7-carboxylate (6.0 g, 12.2 mmol) in DMF (50 mL) under nitrogen at zero degrees C. was added sodium methoxide (49.40 mL, 24.70 mmol, 0.5 M in Methanol). The cold solution was allowed to stir for one hour. Acetic acid (1.64 mL, 27.4 mmol) was added followed by water to precipitate the product. The mixture was allowed to stand for one hour. The crude reaction was filtered and the solids were washed with 1:1 methanol:water and dried in vacuo to afford the desired product.

1. customat zero degrees C
2. customto precipitate the product
3. waitto stand for one hour
4. customThe crude reaction
5. filtrationwas filtered
6. washthe solids were washed with 1:1 methanol
7. dry with materialwater and dried in vacuo