Sodium Hydroxide → HCID 68897208, compound

HRID 897377Notes

Reaction equation

HRID 897377 reaction equation
[CH3:1][N:2]([CH3:36])[S:3]([C:6]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:7]=1[CH2:8][NH:9][C:10]([C:12]1[C:21]([OH:22])=[C:20]2[C:15]([CH:16]=[CH:17][CH:18]=[N:19]2)=[C:14]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][S:24]2(=[O:30])=[O:29])[N:13]=1)=[O:11])(=[O:5])=[O:4].[OH-].[Na+:38]>C(#N)C>[CH3:1][N:2]([CH3:36])[S:3]([C:6]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:7]=1[CH2:8][NH:9][C:10]([C:12]1[C:21]([O-:22])=[C:20]2[C:15]([CH:16]=[CH:17][CH:18]=[N:19]2)=[C:14]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][S:24]2(=[O:30])=[O:29])[N:13]=1)=[O:11])(=[O:5])=[O:4].[Na+:38]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 16728075HCID 16728075, compound

Product 1

HCID 68897208HCID 68897208, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a suspension of N-{2-[(dimethylamino)sulfonyl]-4-fluorobenzyl}-5-(1,1-dioxido-1,2-thiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamide (147 mg, 0.27 mmol) in acetonitrile (1 mL) was added 1N sodium hydroxide (287 μL, 0.29 mmol). After the solution became homogeneous, the sample was concentrated in vacuo to afford the title compound as a yellow solid.

Workup

  1. concentrationthe sample was concentrated in vacuo

Sources & evidence

ORD record
ord-84949087ba9a4ab6bd211db603cb757b
Source dataset
uspto-grants-2005_07
Patent number
US06921759B2

Reaction notes

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