Hydrochloric Acid → HCID 178517542, compound

HRID 897402Notes

Reaction equation

HRID 897402 reaction equation
CS[C:3]1[N:8]2[CH:9]=[N:10][N:11]=[C:7]2[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)=[C:5]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([Cl:28])[CH:23]=2)[N:4]=1.[OH-:29].[Na+].Cl>O1CCOCC1>[OH:29][C:3]1[N:8]2[CH:9]=[N:10][N:11]=[C:7]2[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)=[C:5]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([Cl:28])[CH:23]=2)[N:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 223465775-Methylthio-7-(2-chloro-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine

Product 1

HCID 178517542HCID 178517542, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1 g of crude 5-methylthio-7-(2-chloro-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine and 15 ml of 2M NaOH in 15 ml 1,4-dioxane in a 150-ml r.b.flask with a stir bar was stirred at 80° C. The basic solution was cooled down to room temperature and neutralized to pH 7.5 with 10% HCl. A precipitate was formed, filtered off and washed with water (2×10 ml). The solid was dried under vacuum at 70° C. overnight to give a solid product; MS m/z (M+H)+ 392.1.

Workup

  1. customA precipitate was formed
  2. filtrationfiltered off
  3. washwashed with water (2×10 ml)
  4. customThe solid was dried under vacuum at 70° C. overnight
  5. customto give a solid product

Sources & evidence

ORD record
ord-064d7f24b5b94b138b557f47a31d57a1
Source dataset
uspto-grants-2005_07
Patent number
US06921762B2

Reaction notes

Loading…