HCID 20816914, compound → HCID 10311940, compound

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Reaction Steps

A solution of 5-{7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-yl}-2-(tert-butoxycarbonyl)-(1R)-2,5-diaza-bicyclo[2.2.1]heptane (240 mg, 0.4 mmole) in ethyl acetate (5 mL) was treated with HCl-ether solution (1M, 4 mL) at room temperature. The suspension was stirred at room temperature for 5 minutes. The resulting precipitate was filtered, washed with ether and dried under vacuum to give the product as a light yellowish solid; MS m/z (M)+ 557.3; C30H27F3N8 requir. 557.4.

Provenance & Evidence