HCID 20816914, compound → HCID 10311940, compound

HRID 897409Notes

Reaction equation

HRID 897409 reaction equation
[C:1]1([C@@H:7]([NH:9][C:10]2[CH:15]=[C:14]([C:16]3[N:21]=[C:20]([N:22]4[CH2:27][C@H:26]5[CH2:28][CH:23]4[CH2:24][N:25]5C(OC(C)(C)C)=O)[N:19]4[CH:36]=[N:37][N:38]=[C:18]4[C:17]=3[C:39]3[CH:44]=[CH:43][CH:42]=[C:41]([C:45]([F:48])([F:47])[F:46])[CH:40]=3)[CH:13]=[CH:12][N:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(OCC)(=O)C>[CH:23]12[CH2:28][CH:26]([NH:25][CH2:24]1)[CH2:27][N:22]2[C:20]1[N:19]2[CH:36]=[N:37][N:38]=[C:18]2[C:17]([C:39]2[CH:44]=[CH:43][CH:42]=[C:41]([C:45]([F:47])([F:48])[F:46])[CH:40]=2)=[C:16]([C:14]2[CH:13]=[CH:12][N:11]=[C:10]([NH:9][C@H:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH3:8])[CH:15]=2)[N:21]=1

Participants

3

Reactant 1

HCID 20816914HCID 20816914, compound

Product 1

HCID 10311940HCID 10311940, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 5-{7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-yl}-2-(tert-butoxycarbonyl)-(1R)-2,5-diaza-bicyclo[2.2.1]heptane (240 mg, 0.4 mmole) in ethyl acetate (5 mL) was treated with HCl-ether solution (1M, 4 mL) at room temperature. The suspension was stirred at room temperature for 5 minutes. The resulting precipitate was filtered, washed with ether and dried under vacuum to give the product as a light yellowish solid; MS m/z (M)+ 557.3; C30H27F3N8 requir. 557.4.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-d061839d0e604d0a9229748336a8149a
Source dataset
uspto-grants-2005_07
Patent number
US06921762B2

Reaction notes

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