反应详情

A mixture of the 6-methoxy-2-(4-nitropheyl)benzothiazbles 5 (22 mg, 0.077 mmol) and tin (II) chloride dihydrate (132 mg, 0.45 mmol) in boiling ethanol was stirred under nitrogen for 4 hrs. Ethanol was evaporated and the residue was dissolved in ethyl acetate (10 mL), washed with 1 N sodium hydroxide (2 mL) and water (5 mL), and dried over MgSO4. Evaporation of the solvent gave 19 mg (97%) of the product 6 as yellow solid.

1. customEthanol was evaporated
2. dissolutionthe residue was dissolved in ethyl acetate (10 mL)
3. washwashed with 1 N sodium hydroxide (2 mL) and water (5 mL)
4. dry with materialdried over MgSO4
5. customEvaporation of the solvent