Sodium Hydroxide → Topiramate sodium trihydrate

HRID 898114Notes

Reaction equation

HRID 898114 reaction equation
[CH3:1][C:2]1([CH3:22])[O:10][C@@H:9]2[C@@H:4]([CH2:5][O:6][C@@:7]3([CH2:16][O:17][S:18]([NH2:21])(=[O:20])=[O:19])[O:13][C:12]([CH3:15])([CH3:14])[O:11][C@H:8]32)[O:3]1.[OH-:23].[Na+:24]>O>[CH3:1][C:2]1([CH3:22])[O:10][C@@H:9]2[C@@H:4]([CH2:5][O:6][C@@:7]3([CH2:16][O:17][S:18]([NH-:21])(=[O:20])=[O:19])[O:13][C:12]([CH3:14])([CH3:15])[O:11][C@H:8]32)[O:3]1.[OH2:23].[OH2:3].[OH2:3].[Na+:24]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 5284627Topiramate2×

Product 1

HCID 72941832Topiramate sodium trihydrate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

0.97 g (2.9 mmols) of topiramate (Cheminor Ltd.), 10 mL distilled water, and 2.8 mL 1N NaOH (2.8 mmol) were added to a glass beaker, warmed on a hotplate to 60° C. and stirred with a TEFLON-coated stir bar on a magnetic stirplate. The solid topiramate dissolved in about 25 minutes.

Workup

  1. additionwere added to a glass beaker

Sources & evidence

ORD record
ord-c638d201f2fd4705bcfdeeccb2f1ea63
Source dataset
uspto-grants-2008_04
Patent number
US07351695B2

Reaction notes

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