反应详情

温度

-70 °C

3,3-Diethoxy-1-propyne (10 mL, 70 mmol) was dissolved under argon in THF (150 mL) and cooled to −70° C. Then a 1.6 M solution of n-butyllithium in hexane (48 mL, 77 mmol) was added slowly at −70° C., then allowed to warm to −30° C. and stirred at −30° C. for 30 min, then cooled again to −70° C. Cyclopropanecarboxylic acid methoxy-methyl-amide (10 g, 77 mmol) was added at once at −70° C. (the temperature rose to −50°) then stirred without cooling until 0° C. was reached, then quenched with sat. NH4Cl solution (20 mL). Extraction: 2×AcOEt, 1× sat. NH4Cl, 1× sat. NaCl. The crude brown oil (15 g) was purified by chromatography on silica gel in heptane/ethyl acetate 10:1. One obtained 6 g (43%) of a yellowish oil. MS: m/z=151(M).

1. temperatureto warm to −30° C.
2. temperaturecooled again to −70° C
3. customrose to −50°
4. stirringthen stirred
5. temperaturewithout cooling until 0° C.
6. customquenched with sat. NH4Cl solution (20 mL)
7. extractionExtraction
8. customThe crude brown oil (15 g) was purified by chromatography on silica gel in heptane/ethyl acetate 10:1