反应详情

(3R)-1-Benzyl-3-ethyl-7-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-1benzyl-3-ethyl-7-fluoro-4-(3-hydroxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (74%). [α]D25=−279° (c=0.0095G/ML, CHCl3); MS (ESI) m/z 405 ([M+H]+); MS (ESI) m/z 403 ([M−H]−); HRMS: calcd for C24H21FN2O3.0.25H2O, 408.6563; found (ESI+), 405.16003; Anal. Calcd for C24H21FN2O3.0.25H2O: C, 70.49; H, 5.30; N, 6.85. Found: C, 70.42; H, 5.19; N, 6.75.