HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one → (3R)-1benzyl-3-ethyl-7-fluoro-4-(3-hydroxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one | HCID 11709655 | — |
| Reactant | (3R)-1-benzyl-3-ethyl-7-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one | HCID 69221455 | — |
| Product | (3R)-1benzyl-3-ethyl-7-fluoro-4-(3-hydroxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one | HCID 11516990 | 74% |
Reaction Steps
(3R)-1-Benzyl-3-ethyl-7-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-1benzyl-3-ethyl-7-fluoro-4-(3-hydroxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (74%). [α]D25=−279° (c=0.0095G/ML, CHCl3); MS (ESI) m/z 405 ([M+H]+); MS (ESI) m/z 403 ([M−H]−); HRMS: calcd for C24H21FN2O3.0.25H2O, 408.6563; found (ESI+), 405.16003; Anal. Calcd for C24H21FN2O3.0.25H2O: C, 70.49; H, 5.30; N, 6.85. Found: C, 70.42; H, 5.19; N, 6.75.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351709B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-1c132960311f467ca65c9d055094388a |
| Source note | uspto-grants-2008_04 |