HRID898234

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6362

2-Iodopropane

C3H7I

结构：CC[C@@H]1C(=O)Nc2ccc(F)cc2N1C(=O)c1ccc(OC)cc1

HCID69223657

未命名化合物

结构：CC[C@@H]1C(=O)N(CC)c2ccc(F)cc2N1C(=O)c1cccc(OC)c1

HCID69223676

未命名化合物

PRODUCTS

生成物

结构：CC[C@@H]1C(=O)N(C(C)C)c2ccc(F)cc2N1C(=O)c1ccc(OC)cc1

HCID69221297

未命名化合物

收率 54%

PROCEDURE

实验过程

(3R)-3-Ethyl-6-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (see Example 8) was treated with isopropyl iodide at reflux according to the procedure for the preparation of (3R)-1,3-diethyl-6-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (see Example 8) to yield (3R)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-1-isopropyl-3,4-dihydroquinoxalin-2(1H)-one (54%). MS (ESI) m/z 371 ([M+H]+).

WORKUP

后处理

temperatureat reflux