HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → (3R)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-1-isopropyl-3,4-dihydroquinoxalin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | (3R)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one | HCID 69223657 | — |
| Reactant | (3R)-1,3-diethyl-6-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one | HCID 69223676 | — |
| Product | (3R)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-1-isopropyl-3,4-dihydroquinoxalin-2(1H)-one | HCID 69221297 | 54% |
Reaction Steps
(3R)-3-Ethyl-6-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (see Example 8) was treated with isopropyl iodide at reflux according to the procedure for the preparation of (3R)-1,3-diethyl-6-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (see Example 8) to yield (3R)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-1-isopropyl-3,4-dihydroquinoxalin-2(1H)-one (54%). MS (ESI) m/z 371 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351709B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-0198c057adaf4d92b5b593a1d2a95a9a |
| Source note | uspto-grants-2008_04 |