Thionyl Chloride → HCID 69205380, compound

HRID 898304Notes

Reaction equation

HRID 898304 reaction equation
S(Cl)([Cl:3])=O.[O:5]1[C:9]2[CH:10]=[CH:11][C:12]([C@@H:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[C@H:16](O)[CH2:15]3)=[CH:13][C:8]=2[O:7][CH2:6]1>ClCCl>[Cl:3][CH:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:14]([C:12]2[CH:11]=[CH:10][C:9]3[O:5][CH2:6][O:7][C:8]=3[CH:13]=2)[CH2:15]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 69204538HCID 69204538, compound

Product 1

HCID 69205380HCID 69205380, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (7 mL) was added with stirring and cooling at 15° C. to a solution of cis-3-(benzo[1,3]dioxol-5-yl)-indan-1-ol (10 g) in dichloromethane (300 mL). The mixture was stirred at rt for 40 min. The mixture was washed twice with water, dried (MgSO4) and evaporated in vacuo to give a quantitative yield of 5-(3-chloroindan-1-yl)benzo[1,3]dioxole as an oil, which was used in the next step without further purification.

Workup

  1. stirringThe mixture was stirred at rt for 40 min
  2. washThe mixture was washed twice with water
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-adf01f0321c84a3fbf9be508d8decf78
Source dataset
uspto-grants-2008_04
Patent number
US07351734B2

Reaction notes

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