反应详情

A mixture of 0.04 mol of ethyl 2-benzyl-3-hydroxybutyrate, 0.045 mol of pyridine, 0.05 mol of benzoyl chloride and 40 ml of dried tetrahydrofuran (THF) was refluxed by heating for 8 hrs, and then was allowed to react at room temperature for further 12 hrs. Upon the completion of the reaction, the reaction mixture was filtered, and the solid component was wished with diethyl ether for three times. The organic phases were combined, wished well with saturated saline, and then dried over anhydrous sodium sulfate. After removing the solvent, residue was subjected to column chromatography to give a colorless liquid. Yield 85%.

1. temperaturewas refluxed
2. temperatureby heating for 8 hrs
3. customto react at room temperature for further 12 hrs
4. customUpon the completion of the reaction
5. filtrationthe reaction mixture was filtered
6. dry with materialdried over anhydrous sodium sulfate
7. customAfter removing the solvent, residue
8. customto give a colorless liquid