Ethyl 2-methylacetoacetate → Ethyl 3-hydroxy-2-methylbutyrate

HRID 898501Notes

Reaction equation

[CH3:1][CH:2]([C:8](=[O:10])[CH3:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(OCC)(=O)CC(C)=O>>[CH3:1][CH:2]([CH:8]([OH:10])[CH3:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

Reactant 2

HCID 701Ethyl 2-methylacetoacetate

HCID 8868Ethyl Acetoacetate

Product 1

HCID 656467Ethyl 3-hydroxy-2-methylbutyrateYield 60%

Procedure

Ethyl 2-methyl-3-hydroxybutyrate was prepared following the procedure as described in step 1) of Preparation Example 2, except for that ethyl 2-methyl-3-oxo-butyrate was used to replace for ethyl acetoacetate. Yield 60%.

Workup

customof Preparation Example 2

Sources & evidence

ORD record: ord-7d7837f930764a739e5eb8268d419efb
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07351778B2

Reaction notes

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