Ethyl Acetoacetate → Pentanoic acid, 2-methyl-3-oxo-, ethyl ester

HRID 898506Notes

Reaction equation

HRID 898506 reaction equation
[C:1]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])[CH2:2][CH3:3].[C:11](OCC)(=O)CC(C)=O>>[CH3:11][CH:5]([C:1](=[O:4])[CH2:2][CH3:3])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

3

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 78656Ethyl 3-oxovalerate

Product 1

HCID 231471Pentanoic acid, 2-methyl-3-oxo-, ethyl esterYield 45%

Procedure

The target product was prepared following the procedure as described in step 1) of Preparation Example 3, except for that ethyl propionylacetate was used to replace for ethyl acetoacetate. Yield 45%.

Workup

  1. customThe target product was prepared
  2. customof Preparation Example 3

Sources & evidence

ORD record
ord-6766ebfb4f44480a9aebe43faacce8d2
Source dataset
uspto-grants-2008_04
Patent number
US07351778B2

Reaction notes

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