Ethyl Acetoacetate → Benzyl 3-hydroxybutanoate

HRID 898508Notes

Reaction equation

[C:1]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].C(OCC)(=O)CC(C)=O>>[OH:4][CH:3]([CH3:5])[CH2:2][C:1]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 142266Benzyl acetoacetate

Product 1

HCID 562226Benzyl 3-hydroxybutanoateYield 48%

Procedure

Benzyl 3-hydroxybutyrate was prepared following the procedure as described in step 1) of Preparation Example 2, except for that benzyl acetoacetate was used to replace for ethyl acetoacetate. Yield 48%.

Workup

customof Preparation Example 2

Sources & evidence

ORD record: ord-0f65021eb577461f855dc7ccd0a8b080
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07351778B2

Reaction notes

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