Hydrochloric Acid → Pentanoic acid, 4-methyl-3-oxo-, butyl ester

HRID 898514Notes

Reaction equation

HRID 898514 reaction equation
[OH-].[Na+].[CH3:3][CH:4]([CH3:18])[C:5](=[O:17])[CH:6](C(=O)C)[C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:8].Cl.C(OCC)C>C(O)C>[CH3:18][CH:4]([CH3:3])[C:5](=[O:17])[CH2:6][C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 14798Sodium HydroxideHCID 87775777HCID 87775777, compound

Product 1

HCID 54432391Pentanoic acid, 4-methyl-3-oxo-, butyl ester

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 42 g of NaOH in 50 ml of ethanol was added 0.1 mol of butyl 4-methyl-2-acetyl-3-oxo-valerate, and the reaction mixture was stirred for 10 hrs. Then to the reaction was added 50 ml of crushed ice, and the mixture was neutralized with hydrochloric acid. Diethyl ether was used to extract product, and the collected organic layer was dried over anhydrous sodium sulfate. The product was obtained by distillation under reduced vacuum.

Workup

  1. extractionto extract product
  2. dry with materialthe collected organic layer was dried over anhydrous sodium sulfate
  3. customThe product was obtained by distillation under reduced vacuum

Sources & evidence

ORD record
ord-ba4843d28ae34eb2a5b0c7346cc1ec89
Source dataset
uspto-grants-2008_04
Patent number
US07351778B2

Reaction notes

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