Ammonium → (6-Bromo-4-methylpyridin-3-yl)(2,5-difluorophenyl)methanol

HRID 89852Notes

Reaction equation

HRID 89852 reaction equation
[Br:6][c:7]1[n:8][cH:9][c:10]([Br:14])[c:11]([CH3:13])[cH:12]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:27][CH2:28][O:29][CH2:30][CH3:31].[CH3:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37].[Cl-:25].[F:15][c:16]1[c:17]([CH:18]=[O:19])[cH:20][c:21]([F:24])[cH:22][cH:23]1.[NH4+:26]>>[Br:6][c:7]1[n:8][cH:9][c:10]([CH:18]([c:17]2[c:16]([F:15])[cH:23][cH:22][c:21]([F:24])[cH:20]2)[OH:19])[c:11]([CH3:13])[cH:12]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 3283Diethyl EtherHCID 8058HexaneHCID 1376632,5-DifluorobenzaldehydeHCID 27344292,5-Dibromo-4-methylpyridineHCID 178418339Butyllithium

Product 1

HCID 57736414(6-Bromo-4-methylpyridin-3-yl)(2,5-difluorophenyl)methanol

Sources & evidence

ORD record
ord-75f32927783a43cba12ead684dacd00c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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