反应详情

5.17 g (32 mol) of CDl are added to a solution of 4.7 g (29 mol) of 4-cyanomethyl-benzoic acid in 250 mL of tetrahydrofuran and stirred until no more gas is given off. This reaction mixture is added dropwise to a solution of 3.29 g (87 mol) of sodium borohydride in 200 mL of water in such a way that the temperature does not exceed 30° C. The mixture is stirred for two hours and the reaction mixture is adjusted to pH 3-4 with potassium hydrogen sulphate solution. Then it is extracted with EtOAc, the organic phase is dried over magnesium sulphate and the solvent is separated off using the rotary evaporator.

1. customdoes not exceed 30° C
2. stirringThe mixture is stirred for two hours
3. extractionThen it is extracted with EtOAc
4. dry with materialthe organic phase is dried over magnesium sulphate
5. customthe solvent is separated off
6. customthe rotary evaporator