(4-Pyrrolidin-1-ylmethyl-phenyl)-acetonitrile → 2-[4-(Pyrrolidin-1-ylmethyl)phenyl]ethanamine

HRID 898537Notes

Reaction equation

HRID 898537 reaction equation
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][C:14]#[N:15])=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>[Ni].N>[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH2:15])=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 59598027(4-Pyrrolidin-1-ylmethyl-phenyl)-acetonitrileHCID 178418361HCID 178418361, compound

Product 1

HCID 164950372-[4-(Pyrrolidin-1-ylmethyl)phenyl]ethanamine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

A reaction mixture of 0.73 g (3.66 mmol) of (4-pyrrolidin-1-ylmethyl-phenyl)-acetonitrile and 0.1 g Raney nickel in 25 mL of methanolic ammonia solution is hydrogenated for 9 hours at 50° C. under 3 bar hydrogen.

Sources & evidence

ORD record
ord-0f56c63fc9fc404798924ce5de258170
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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