HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Pyrrolidin-1-ylmethyl-phenyl)-acetonitrile → 2-[4-(Pyrrolidin-1-ylmethyl)phenyl]ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Pyrrolidin-1-ylmethyl-phenyl)-acetonitrile | HCID 59598027 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 2-[4-(Pyrrolidin-1-ylmethyl)phenyl]ethanamine | HCID 16495037 | — |
Reaction Steps
A reaction mixture of 0.73 g (3.66 mmol) of (4-pyrrolidin-1-ylmethyl-phenyl)-acetonitrile and 0.1 g Raney nickel in 25 mL of methanolic ammonia solution is hydrogenated for 9 hours at 50° C. under 3 bar hydrogen.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351719B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-0f56c63fc9fc404798924ce5de258170 |
| Source note | uspto-grants-2008_04 |