Ammonia → HCID 59691680, compound

HRID 898542Notes

Reaction equation

HRID 898542 reaction equation
[CH2:1]([N:3]([CH2:20][CH3:21])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])[CH3:2].Cl.N>>[CH2:20]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])[CH3:21]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 68818446HCID 68818446, compound

Product 1

HCID 59691680HCID 59691680, compound

Procedure

A solution of 1.85 g (6.264 mmol) N-[4-(2-diethylamino-ethoxy)-3-nitro-phenyl]-acetamide (Z31a) in semiconc. aqueous HCl was stirred for 2 h at 100° C., cooled to RT, made basic with ice and conc. aqueous ammonia and the aqueous phase was exhaustively extracted with EtOAc. The combined org. phases were washed with water and dried over sodium sulphate.

Workup

  1. extractionthe aqueous phase was exhaustively extracted with EtOAc
  2. washphases were washed with water
  3. dry with materialdried over sodium sulphate

Sources & evidence

ORD record
ord-c2bf1d3411e1473d8f9f5c1b9f5027db
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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