Hydrochloric Acid → HCID 59691634, compound

HRID 898544Notes

Reaction equation

HRID 898544 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13](/[CH:16]=[CH:17]/[C:18]([O:20]CC)=[O:19])=[N:14][CH:15]=2)=[CH:6][CH:5]=1.Cl>CCO>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])=[N:14][CH:15]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68874073ethyl (E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-acrylate

Product 1

HCID 59691634HCID 59691634, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

12.6 mL aqueous NaOH (1 M) was added at RT to a suspension of 1.200 g (4.200 mmol) ethyl (E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-acrylate (Z34a) in 50 mL EtOH and the mixture was stirred for 1 h . 12.6 mL aqueous HCl (1 M) was added at 0° C. The precipitate formed was filtered off, washed with water and dried i. vac. at 100° C.

Workup

  1. customThe precipitate formed
  2. filtrationwas filtered off
  3. washwashed with water
  4. customdried i
  5. customat 100° C.

Sources & evidence

ORD record
ord-713686cbe90049229fe8e1746e3a30a9
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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