HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Chloro-4-nitro-benzyl)-diethyl-amine → 3-Chloro-4-diethylaminomethyl-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Chloro-4-nitro-benzyl)-diethyl-amine | HCID 68876192 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Chloro-4-diethylaminomethyl-phenylamine | HCID 28721821 | — |
Reaction Steps
A suspension of 0.700 g (2.884 mmol) (2-chloro-4-nitro-benzyl)-diethyl-amine (Z35a) and 0.400 g Raney nickel in 20 mL THF was hydrogenated for 7.5 h at RT and 25 psi. The catalyst was filtered off and the filtrate was evaporated down i. vac. The crude product was purified by column chromatography (Alox, neutral, act. II-III, petroleum ether/EtOAc 4:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351719B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-46dbcf91156446f79b5ae9e1508b92ab |
| Source note | uspto-grants-2008_04 |