HCID 5709520, compound → (e)-n-[3-Chloro-4-(3-hydroxy-propyl)-phenyl]-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide

HRID 898554Notes

Reaction equation

HRID 898554 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1/[CH:12]=[CH:13]/[C:14]([OH:16])=O.[Cl:17][C:18]1[CH:23]=[C:22]([N+:24]([O-])=O)[CH:21]=[CH:20][C:19]=1[CH2:27][CH2:28][CH2:29][OH:30]>>[Cl:17][C:18]1[CH:23]=[C:22]([NH:24][C:14](=[O:16])/[CH:13]=[CH:12]/[C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=2[Cl:1])[CH:21]=[CH:20][C:19]=1[CH2:27][CH2:28][CH2:29][OH:30]

Participants

3

Reactant 2

HCID 5709520HCID 5709520, compoundHCID 688779703-(2-Chloro-4-nitro-phenyl)-propan-1-ol

Product 1

HCID 68878212(e)-n-[3-Chloro-4-(3-hydroxy-propyl)-phenyl]-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide

Procedure

Prepared analogously to Intermediate product Z32a starting from (E)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylic acid (Z37b) and 3-(2-chloro-4-nitro-phenyl)-propan-1-ol. The crude product was purified by column chromatography (silica gel, petroleum ether/EtOAc 1:1).

Workup

  1. customPrepared analogously to Intermediate product Z32a
  2. customThe crude product was purified by column chromatography (silica gel, petroleum ether/EtOAc 1:1)

Sources & evidence

ORD record
ord-589b042339aa4505a9449eb8a2a8a466
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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