Hydrochloric Acid → HCID 68875873, compound

HRID 898579Notes

Reaction equation

HRID 898579 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:16]=[C:15]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:14]=[CH:13][C:5]=1[O:6][CH2:7][C:8]([O:10]CC)=[O:9].CCO.Cl>O>[Cl:3][C:4]1[CH:16]=[C:15]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:14]=[CH:13][C:5]=1[O:6][CH2:7][C:8]([OH:10])=[O:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 85969218HCID 85969218, compound

Product 1

HCID 68875873HCID 68875873, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

250 mg (6.250 mmol) NaOH in 10 mL water was added to a solution of 0.400 g (1.371 mmol) ethyl (2-chloro-4-pyridin-3-yl-phenoxy)-acetate in 40 mL abs. EtOH and the mixture was stirred for 1 h at RT. The reaction mixture was acidified with aqueous HCl (1 M) to pH 7.5, the precipitate was filtered off and washed with water.

Workup

  1. filtrationthe precipitate was filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-27f083bce1e1477ebb4d81379b05d6ad
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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