Trifluoroacetic acid → HCID 23036785, compound

HRID 898581Notes

Reaction equation

HRID 898581 reaction equation
C(O)(C(F)(F)F)=O.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([O:25]C(C)(C)C)=[O:24])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>ClCCl>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 85971735HCID 85971735, compound

Product 1

HCID 23036785HCID 23036785, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 mL TFA was added to a solution of 0.750 g (2.000 mmol) tert-butyl (4′-chloro-biphenyl-4-yloxy)-acetate in 20 mL dichloromethane and the mixture was stirred for 16 h at RT. The reaction mixture was evaporated down i. vac. and diluted with 1 M aqueous NaOH and EtOAc. The precipitate was filtered off and dried at 80° C. i. vac.

Workup

  1. customThe reaction mixture was evaporated down i
  2. additionand diluted with 1 M aqueous NaOH and EtOAc
  3. filtrationThe precipitate was filtered off
  4. customdried at 80° C. i

Sources & evidence

ORD record
ord-44521ec2a9214f5ca847bea603090a6b
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

Loading…