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HRID898596

反应详情

EQUATION

反应方程式

HRID 898596 的结构方程式

REACTANTS

反应物

2
结构：C1=CCNC1
HCID66059

1H-Pyrrole, 2,5-dihydro-

C4H7N

结构：O=C(COc1ccc(C(F)(F)F)cc1Cl)Nc1ccc(OCCBr)c(Cl)c1
HCID59691643

未命名化合物

PRODUCTS

生成物

1
结构：O=C(COc1ccc(C(F)(F)F)cc1Cl)Nc1ccc(OCCN2CC=CC2)c(Cl)c1
HCID10027901

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(C(C)C)C(C)C
溶剂HCID81531

Diisopropylethylamine

C8H19N

PROCEDURE

实验过程

A solution of 0.145 g (0.300 mmol) of N-[4-(2-bromo-ethoxy)-3-chloro-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide (Z28b) and 30.6 μL (0.400 mmol) 2,5-dihydro-1H-pyrrole in 2 mL Hünig base was stirred for 3h at 80° C. and then evaporated down i. vac. Column chromatography (Alox, neutral, act. II-III, gradient dichloromethane/MeOH 20:0→19:1) yielded the product.

WORKUP

后处理

  1. customevaporated down i
  2. customColumn chromatography (Alox, neutral, act. II-III, gradient dichloromethane/MeOH 20:0→19:1) yielded the product