HCID 10005777, compound → n-[3-Amino-4-(2-diethylamino-ethoxy)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

HRID 898605Notes

Reaction equation

HRID 898605 reaction equation
[Cl:1][C:2]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:3]=1[O:4][CH2:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[C:11]([N+:23]([O-])=O)[CH:10]=1)=[O:7]>[Ni]>[NH2:23][C:11]1[CH:10]=[C:9]([NH:8][C:6](=[O:7])[CH2:5][O:4][C:3]2[CH:26]=[CH:27][C:28]([C:30]([F:31])([F:32])[F:33])=[CH:29][C:2]=2[Cl:1])[CH:14]=[CH:13][C:12]=1[O:15][CH2:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22]

Participants

3

Reactant 1

HCID 10005777HCID 10005777, compound

Product 1

HCID 59691580n-[3-Amino-4-(2-diethylamino-ethoxy)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

A suspension of 330 mg (0.674 mmol) 2-(2-chloro-4-trifluoromethyl-phenoxy)-N-[4-(2-diethylamino-ethoxy)-3-nitro-phenyl]-acetamide (Example 160) and 200 mg Raney nickel was hydrogenated at RT and 3 bar. The catalyst was filtered off and the filtrate evaporated down i. vac.

Workup

  1. customwas hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated down i

Sources & evidence

ORD record
ord-7f6fd77679034f6bb82333f8582a1612
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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