Ethyl bromoacetate → Ethyl (2-fluoro-4-trifluoromethyl-phenylamino)-acetate

HRID 898611ノート

反応式

HRID 898611 の反応式
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH2:12].Br[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

参加物

3

反応物 2

HCID 7748Ethyl bromoacetateHCID 27376742-Fluoro-4-(trifluoromethyl)aniline

生成物 1

HCID 85969232Ethyl (2-fluoro-4-trifluoromethyl-phenylamino)-acetate

実験手順

Prepared analogously to Example 165a starting from 2-fluoro-4-trifluoromethyl-phenylamine and ethyl bromoacetate. The crude product was purified by column chromatography (silica gel, gradient dichloromethane/MeOH 20:0→19:1).

後処理

  1. customPrepared analogously to Example 165a
  2. customThe crude product was purified by column chromatography (silica gel, gradient dichloromethane/MeOH 20:0→19:1)

出典と根拠

ORDレコード
ord-2cabaa15feaf4d559437a962fb4cb190
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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