4-Methylpiperidine → n-[3-Chloro-4-(4-methyl-piperidin-1-ylmethyl)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

Participants

Reaction Steps

0.24 mL (2.000 mmol) 4-methylpiperidine was added to a solution of 0.206 g (0.500 mmol) N-(3-chloro-4-chloromethyl-phenyl)-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide (Z32b) in 5 mL abs. THF and the mixture was refluxed for 2 h. The reaction mixture was poured onto ice water, the precipitate was filtered off, washed with water and dried in a HV.

Provenance & Evidence