4-Methylpiperidine → n-[3-Chloro-4-(4-methyl-piperidin-1-ylmethyl)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

HRID 898616Notes

Reaction equation

HRID 898616 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Cl:8][C:9]1[CH:10]=[C:11]([NH:17][C:18](=[O:32])[CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=2[Cl:31])[CH:12]=[CH:13][C:14]=1[CH2:15]Cl>C1COCC1>[Cl:8][C:9]1[CH:10]=[C:11]([NH:17][C:18](=[O:32])[CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:29])([F:30])[F:28])=[CH:23][C:22]=2[Cl:31])[CH:12]=[CH:13][C:14]=1[CH2:15][N:5]1[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 693814-MethylpiperidineHCID 59691573HCID 59691573, compound

Product 1

HCID 59691654n-[3-Chloro-4-(4-methyl-piperidin-1-ylmethyl)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.24 mL (2.000 mmol) 4-methylpiperidine was added to a solution of 0.206 g (0.500 mmol) N-(3-chloro-4-chloromethyl-phenyl)-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide (Z32b) in 5 mL abs. THF and the mixture was refluxed for 2 h. The reaction mixture was poured onto ice water, the precipitate was filtered off, washed with water and dried in a HV.

Workup

  1. additionThe reaction mixture was poured onto ice water
  2. filtrationthe precipitate was filtered off
  3. washwashed with water
  4. customdried in a HV

Sources & evidence

ORD record
ord-2d02a0d5ea604d28b039d29142189805
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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