反应详情

A suspension of 0.200 g (0.464 mmol) (E)-3-(4′-chloro-biphenyl-4-yl)-N-(4-piperidin-1-ylmethyl-phenyl)-acrylamide (Example 172) and 100 mg Raney nickel in 50 mL EtOAc was hydrogenated at RT and 50 psi. The catalyst was filtered off, the filtrate was evaporated down i. vac. and the residue was triturated with ether. The precipitate was filtered off, washed with ether and dried at 50° C. i. vac.

1. customwas hydrogenated at RT
2. filtrationThe catalyst was filtered off
3. customthe filtrate was evaporated down i
4. customand the residue was triturated with ether
5. filtrationThe precipitate was filtered off
6. washwashed with ether
7. customdried at 50° C. i