4-((4-Methylpiperazin-1-yl)methyl)aniline → (e)-3-(4'-Chloro-biphenyl-4-yl)-n-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acrylamide

HRID 898620Notes

Reaction equation

HRID 898620 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[C:16]([OH:18])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:19][N:20]1[CH2:25][CH2:24][N:23]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=2)[CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[C:16]([NH:33][C:30]3[CH:29]=[CH:28][C:27]([CH2:26][N:23]4[CH2:22][CH2:21][N:20]([CH3:19])[CH2:25][CH2:24]4)=[CH:32][CH:31]=3)=[O:18])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 31539964-((4-Methylpiperazin-1-yl)methyl)anilineHCID 5957595HCID 5957595, compound

Product 1

HCID 59691672(e)-3-(4'-Chloro-biphenyl-4-yl)-n-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acrylamide

Procedure

Prepared analogously to Example 172 starting from (E)-3-(4′-chloro-biphenyl-4-yl)-acrylic acid and 4-(4-methyl-piperazin-1-ylmethyl)-phenylamine. The crude product was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:0.1).

Workup

  1. customThe crude product was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:0.1)

Sources & evidence

ORD record
ord-bd37337327dd4c3780e68c0c113e8f89
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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