HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((4-Methylpiperazin-1-yl)methyl)aniline → (e)-3-(4'-Chloro-biphenyl-4-yl)-n-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((4-Methylpiperazin-1-yl)methyl)aniline | HCID 3153996 | — |
| Reactant | HCID 5957595 | HCID 5957595 | — |
| Product | (e)-3-(4'-Chloro-biphenyl-4-yl)-n-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acrylamide | HCID 59691672 | — |
Reaction Steps
Prepared analogously to Example 172 starting from (E)-3-(4′-chloro-biphenyl-4-yl)-acrylic acid and 4-(4-methyl-piperazin-1-ylmethyl)-phenylamine. The crude product was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:0.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351719B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-bd37337327dd4c3780e68c0c113e8f89 |
| Source note | uspto-grants-2008_04 |