3-(Pyridin-2-yl)prop-2-enoic acid → HCID 59691598, compound

HRID 898624Notes

Reaction equation

HRID 898624 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1/[CH:7]=[CH:8]/[C:9]([OH:11])=O.[Cl:12][C:13]1[CH:14]=[C:15]([NH2:27])[CH:16]=[CH:17][C:18]=1[O:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24]>>[Cl:12][C:13]1[CH:14]=[C:15]([NH:27][C:9](=[O:11])/[CH:8]=[CH:7]/[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:16]=[CH:17][C:18]=1[O:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24]

Participants

3

Reactant 2

HCID 53566263-(Pyridin-2-yl)prop-2-enoic acidHCID 167916763-Chloro-4-(2-diethylaminoethoxy)phenylamine

Product 1

HCID 59691598HCID 59691598, compound

Procedure

Prepared analogously to Example 172 starting from (E)-3-pyridin-2-yl-acrylic acid and 3-chloro-4-(2-diethylamino-ethoxy)-phenylamine (Z2b) at RT (72 h). The crude product was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:0.1) and recrystallisation from petroleum ether.

Workup

  1. customThe crude product was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:0.1) and recrystallisation from petroleum ether

Sources & evidence

ORD record
ord-77b89fa1454242239e4f6e19fc6c7663
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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