4-(2-Dimethylaminoethyl)aniline → (E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-N-[4-(2-dimethylamino-ethyl)-phenyl]-acrylamide

Participants

Role	Name	HCID	Charge
Reactant	4-(2-Dimethylaminoethyl)aniline	HCID 14939861	—
Reactant	(e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-acrylic acid	HCID 59691634	—
Product	(E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-N-[4-(2-dimethylamino-ethyl)-phenyl]-acrylamide	HCID 59691592	—

Reaction Steps

Prepared analogously to Example 143 starting from (E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-acrylic acid (Z34b) and 4-(2-dimethylamino-ethyl)-phenylamine. The crude product was purified by column chromatography (silica gel, dichloromethane/EtOH/conc. aqueous ammonia 50:10:0.1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07351719B2
Source dataset	uspto-grants-2008_04
ORD ID	ord-8c975eefa32146e882da5623148717a5
Source note	uspto-grants-2008_04