Methyl-(4-piperidin-1-ylmethyl-phenyl)-amine → (e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-n-methyl-n-(4-piperidin-1-ylmethyl-phenyl)-acrylamide

HRID 898627Notes

Reaction equation

HRID 898627 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[C:16]([OH:18])=O)=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[CH3:19][NH:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[C:16]([N:20]([CH3:19])[C:21]3[CH:22]=[CH:23][C:24]([CH2:27][N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:25][CH:26]=3)=[O:18])=[N:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 18319987Methyl-(4-piperidin-1-ylmethyl-phenyl)-amineHCID 59691634HCID 59691634, compound

Product 1

HCID 59691652(e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-n-methyl-n-(4-piperidin-1-ylmethyl-phenyl)-acrylamide

Procedure

Prepared analogously to Example 143 starting from (E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-acrylic acid (Z34b) and methyl-(4-piperidin-1-ylmethyl-phenyl)-amine. The crude product was purified by column chromatography (silica gel, dichloromethane/EtOH/conc. aqueous ammonia 50:10:0.1).

Workup

  1. customThe crude product was purified by column chromatography (silica gel, dichloromethane/EtOH/conc. aqueous ammonia 50:10:0.1)

Sources & evidence

ORD record
ord-320c9d7acbe8458197d8bfbc0279745c
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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