HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl-(4-piperidin-1-ylmethyl-phenyl)-amine → (e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-n-methyl-n-(4-piperidin-1-ylmethyl-phenyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl-(4-piperidin-1-ylmethyl-phenyl)-amine | HCID 18319987 | — |
| Reactant | (e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-acrylic acid | HCID 59691634 | — |
| Product | (e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-n-methyl-n-(4-piperidin-1-ylmethyl-phenyl)-acrylamide | HCID 59691652 | — |
Reaction Steps
Prepared analogously to Example 143 starting from (E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-acrylic acid (Z34b) and methyl-(4-piperidin-1-ylmethyl-phenyl)-amine. The crude product was purified by column chromatography (silica gel, dichloromethane/EtOH/conc. aqueous ammonia 50:10:0.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351719B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-320c9d7acbe8458197d8bfbc0279745c |
| Source note | uspto-grants-2008_04 |