HCID 5709520, compound → (e)-n-(3-Chloro-4-diethylaminomethyl-phenyl)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide

HRID 898628Notes

Reaction equation

HRID 898628 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1/[CH:12]=[CH:13]/[C:14]([OH:16])=O.[Cl:17][C:18]1[CH:19]=[C:20]([NH2:30])[CH:21]=[CH:22][C:23]=1[CH2:24][N:25]([CH2:28][CH3:29])[CH2:26][CH3:27]>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:30][C:14](=[O:16])/[CH:13]=[CH:12]/[C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=2[Cl:1])[CH:21]=[CH:22][C:23]=1[CH2:24][N:25]([CH2:28][CH3:29])[CH2:26][CH3:27]

Participants

3

Reactant 2

HCID 5709520HCID 5709520, compoundHCID 287218213-Chloro-4-diethylaminomethyl-phenylamine

Product 1

HCID 59691581(e)-n-(3-Chloro-4-diethylaminomethyl-phenyl)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide

Procedure

Prepared analogously to Example 143 starting from (E)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylic acid (Z37b) and 3-chloro-4-diethylaminomethyl-phenylamine (Z35b). The crude product was purified by column chromatography (Alox, neutral, act. II-III, petroleum ether/EtOAc 3:1).

Workup

  1. customThe crude product was purified by column chromatography (Alox, neutral, act. II-III, petroleum ether/EtOAc 3:1)

Sources & evidence

ORD record
ord-e12f58a1fc7443fcbe33adafa995091f
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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