HCID 5709520, compound → HCID 59691545, compound

HRID 898629Notes

Reaction equation

HRID 898629 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1/[CH:12]=[CH:13]/[C:14]([OH:16])=O.[Cl:17][C:18]1[CH:19]=[C:20]([NH2:32])[CH:21]=[CH:22][C:23]=1[CH2:24][N:25]1[CH2:30][CH2:29][CH:28]([CH3:31])[CH2:27][CH2:26]1>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:32][C:14](=[O:16])/[CH:13]=[CH:12]/[C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=2[Cl:1])[CH:21]=[CH:22][C:23]=1[CH2:24][N:25]1[CH2:26][CH2:27][CH:28]([CH3:31])[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 5709520HCID 5709520, compoundHCID 287218443-Chloro-4-(4-methyl-piperidin-1-ylmethyl)-phenylamine

Product 1

HCID 59691545HCID 59691545, compound

Procedure

Prepared analogously to Example 143 starting from (E)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylic acid (Z37b) and 3-chloro-4-(4-methyl-piperidin-1-ylmethyl)-phenylamine (Z36b). The crude product was purified by column chromatography (Alox, neutral, act. II-III, petroleum ether/EtOAc 3:1).

Workup

  1. customThe crude product was purified by column chromatography (Alox, neutral, act. II-III, petroleum ether/EtOAc 3:1)

Sources & evidence

ORD record
ord-f15a64e1f52f4cd491e5c85ccc838b1c
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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