HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 5709520, compound → (e)-n-{3-Chloro-4-[2-(4-methyl-piperidin-1-yl)-ethyl]-phenyl}-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 5709520 | HCID 5709520 | — |
| Reactant | 3-Chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine | HCID 59691670 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (e)-n-{3-Chloro-4-[2-(4-methyl-piperidin-1-yl)-ethyl]-phenyl}-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide | HCID 59691697 | — |
Reaction Steps
Prepared in DMF analogously to Example 143 starting from (E)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylic acid (Z37b) and 3-chloro-4-[2-(4-methyl-piperidin-1-yl)-ethyl]-phenylamine (Z46c). The crude product was purified by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 3:1→2:1) and then triturated with petroleum ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351719B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-e324a045fe2749d0909644cb883d3529 |
| Source note | uspto-grants-2008_04 |