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HRID898634

反应详情

EQUATION

反应方程式

HRID 898634 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)/C=C/c1ccc(C(F)(F)F)cc1Cl
HCID5709520

未命名化合物

结构：CC1CCN(CCc2ccc(N)cc2Cl)CC1
HCID59691670

未命名化合物

PRODUCTS

生成物

1
结构：CC1CCN(CCc2ccc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3Cl)cc2Cl)CC1
HCID59691697

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared in DMF analogously to Example 143 starting from (E)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylic acid (Z37b) and 3-chloro-4-[2-(4-methyl-piperidin-1-yl)-ethyl]-phenylamine (Z46c). The crude product was purified by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 3:1→2:1) and then triturated with petroleum ether.

WORKUP

后处理

  1. customThe crude product was purified by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 3:1→2:1)
  2. customtriturated with petroleum ether