HCID 69213104, compound → HCID 86589928, compound

HRID 898663Notes

Reaction equation

HRID 898663 reaction equation
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11]CC2C=CC=CC=2)=[C:7]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]=1[F:23])(=[O:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]=1[F:23])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 69213104HCID 69213104, compound2×

Product 1

HCID 86589928HCID 86589928, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Following General Procedure G and using tert-butyl-4-benzyloxy-2-fluoro-phenyl acetate (Compound 13, 2.2 g, 6.96 mmol), ethyl acetate (15 mL) and 5% palladium on carbon (0.436 g) the title compound was obtained as a white solid (1.5 g, 95%).

Sources & evidence

ORD record
ord-8e38d5fb78eb4fa5a901682d13558739
Source dataset
uspto-grants-2008_04
Patent number
US07351737B2

Reaction notes

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