反应详情

To a solution of 6-chloro-3-chloroethyl-4-propyl-pyridazine (3.4 g, 16.58 mmol) in CH3CN (30 ml) is added K2CO3 (9.15 g, 66.3 mmol), isobutylamine (6.6 ml, 66.3 mmol) and the mixture is stirred at room temperature overnight. The solvent is removed in vacuo and to the residue is added water (60 ml) and EtOAc (60 ml). The layers are separated and the organic layer is washed with brine (20 ml) and dried (Na2SO4). Evaporation of the solvent provides a light yellow oil, which is used to next step without further purification.

1. customThe solvent is removed in vacuo and to the residue
2. additionis added water (60 ml) and EtOAc (60 ml)
3. customThe layers are separated
4. washthe organic layer is washed with brine (20 ml)
5. dry with materialdried (Na2SO4)
6. customEvaporation of the solvent
7. customprovides a light yellow oil, which
8. customis used to next step without further purification