Water → 4-[1-(3,4-Dimethoxyphenoxy)-4-hydroxybutyl]benzonitrile

HRID 898769Notes

Reaction equation

HRID 898769 reaction equation
B.CSC.[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[O:10][CH:11]([C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=1)[CH2:12][CH:13]=[CH2:14].O.B1([O-])O[O:30]1.O.O.O.O.[Na+]>C1COCC1>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[O:10][CH:11]([C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=1)[CH2:12][CH2:13][CH2:14][OH:30]

Participants

6

Reactant 4

HCID 962Water2×HCID 12423031(Dimethyl sulfide)trihydroboronHCID 218676894-[1-(3,4-Dimethoxyphenoxy)-3-butenyl]benzonitrileHCID 23693097Sodium;3-oxidodioxaborirane;tetrahydrate

Product 1

HCID 218677264-[1-(3,4-Dimethoxyphenoxy)-4-hydroxybutyl]benzonitrileYield 78%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Borane-methyl sulfide complex (2 M in ether, 11 mL, 22 mmol) was added dropwise to a cooled (−5° C.) solution of 4-[1-(3,4-dimethoxyphenoxy)-3-butenyl]benzonitrile (from step (i) above; 17.6 g, 56.8 mmol) in dry THF (15 mL) over a period of 15 minutes (during which time the reaction temperature rose to 0° C.). The resulting mixture was stirred at between 0 and 10° C. for 1.5 h, before being allowed to warm to rt. Stirring was continued for a further 3.5 h at this temperature before water (22 mL) and sodium perborate tetrahydrate (11 g, 66 mmol) were added. The biphasic mixture was stirred for 2 h at rt before the water layer was separated and extracted with ether. The combined organic layers were washed with brine, dried and concentrated in vacuo. The resulting residue was purified by chromatography on silica gel, eluting with IPA:ethyl acetate:heptane (5:25:70) to yield 14.5 g (77%) of the sub-title compound.

Workup

  1. customrose to 0° C.
  2. stirringStirring
  3. additionwere added
  4. customwas separated
  5. extractionextracted with ether
  6. washThe combined organic layers were washed with brine
  7. customdried
  8. concentrationconcentrated in vacuo
  9. customThe resulting residue was purified by chromatography on silica gel
  10. washeluting with IPA:ethyl acetate:heptane (5:25:70)

Sources & evidence

ORD record
ord-88e1acb13105450a91359be69c716c4b
Source dataset
uspto-grants-2008_04
Patent number
US07351821B2

Reaction notes

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