反应详情

温度

130 °C

To the 2-diazomalonic acid t-butyl ester (Z)-3-phenyl-allyl ester (16 g, 54 mmol) above were added triethyl phosphite (0.090 g, 0.54 mmol) and copper (I) iodide (0.10 g, 0.54 mmol) in toluene (490 mL). After heating at 130° C. for 5 hours, the solid was filtered off and the filtrate was concentrated. The reaction mixture was purified by column chromatography using dichloromethane as an eluent. Purification afforded 5.2 g of the desired diastereomer and 2.8 g of the other diastereomer.

1. filtrationthe solid was filtered off
2. concentrationthe filtrate was concentrated
3. customThe reaction mixture was purified by column chromatography
4. customPurification
5. customafforded 5.2 g of the desired diastereomer and 2.8 g of the other diastereomer