HCID 86623927, compound → HCID 86623928, compound

HRID 898845Notes

Reaction equation

HRID 898845 reaction equation
C([O:5][C:6]([C@:8]1([C:20](=[O:25])[N:21]([O:23][CH3:24])[CH3:22])[C@@H:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C@H:9]1[CH2:17][O:18][CH3:19])=[O:7])(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[CH3:19][O:18][CH2:17][C@@H:9]1[C@H:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C@@:8]1([C:20](=[O:25])[N:21]([O:23][CH3:24])[CH3:22])[C:6]([OH:7])=[O:5]

Participants

4

Reactant 1

HCID 86623927HCID 86623927, compound

Product 1

HCID 86623928HCID 86623928, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

(1R*,2R*,3R*)-2-methoxymethyl-1-(methoxy-methyl-carbamoyl)-3-phenyl-cyclopropanecarboxylic acid t-butyl ester (30 mg, 0.086 mmol) was dissolved in 1 mL of trifluoroacetic acid and 1 mL of dichloromethane. After stirring at room temperature for 2 hours, the reaction mixture was concentrated and azeotroped with toluene. The product was dried under high vacuum before use.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customazeotroped with toluene
  3. customThe product was dried under high vacuum before use

Sources & evidence

ORD record
ord-f268aa7af96d459cadaede7e85ebb8c0
Source dataset
uspto-grants-2008_04
Patent number
US07351825B2

Reaction notes

Loading…