反应详情

N-(2,4-difluorobenzyl)-N-heptylamine (2.004 g, 8.304 mmol) was dissolved in DCM (30 ml). It was then cooled in an ice-bath. Triethylamine (1.092 g, 10.796 mmol) was added and then bromacetyl chloride (1.438 g, 9.135 mmol) was dropped in. The mixture was stirred for 2 hours (ice-bath). It was then washed with water (with additional of 1% hydrochloric acid, pH-3), water and brine, and dried (magnesium sulphate) and evaporated. The crude oil product was dissolved in DCM, then loaded onto a column (ISOLUTE®SI 5 g/25 ml) and eluted with more DCM. Oil product 2.412 g was obtained, yield 80%

1. temperatureIt was then cooled in an ice-bath
2. washIt was then washed with water (with additional of 1% hydrochloric acid, pH-3), water and brine
3. dry with materialdried (magnesium sulphate)
4. customevaporated
5. dissolutionThe crude oil product was dissolved in DCM
6. washeluted with more DCM